| 角色 | 饰演者 | 角色介绍 |
| Rango / Lars (voice) | 约翰尼·德普 | |
| Beans (voice) | 艾拉·菲舍尔 | |
| Priscilla (voice) | 阿比吉尔·布莱斯林 | |
| Mayor (voice) | 尼德·巴蒂 | |
| Roadkill (voice) | 阿尔弗雷德·莫里纳 | |
| Rattlesnake Jake (voice) | 比尔·奈伊 | |
| Doc / Merrimack / Mr. Snuggles (voice) | 斯蒂芬·鲁特 | |
| Balthazar (voice) | 哈利·戴恩·斯坦通 | |
| Spirit of the West (voice) | 蒂莫西·奥利芬特 | |
| Bad Bill (voice) | 雷·温斯顿 | |
| Ambrose (voice) | 伊安·艾伯克龙比 | |
| Wounded Bird (voice) | 吉尔·伯明翰 | |
| Waffles / GordyPapa / Joad / Cousin Murt / Curlie Knife Attacker / Rodent Kid (voice) | James Ward Byrkit | |
| Angelique (voice) | 克劳迪娅·布莱克 | |
| Buford (voice) | 布莱克·克拉克 | |
| Elgin (voice) (as John Cothran) | John Cothran Jr. | |
| Delilah / Maybelle (voice) | Patrika Darbo | |
| Se?or Flan - Mariachi Accordion (voice) | George Del Hoyo | |
| Lucky (voice) | Maile Flanagan | |
| Elbows (voice) | Charles Fleischer | |
| Bonnie (voice) | 贝丝·格兰特 | |
| Jedidiah (voice) | Ryan Hurst | |
| Ezekiel / Lasso Rodent (voice) | 文森特·卡塞瑟 | |
| Chorizo (voice) | Hemky Madera | |
| Spoons (voice) | Alex Manugian | |
| Parsons (voice) | Mark 'Crash' McCreery | |
| Rock-Eye (voice) | 乔·努奈兹 |
